Detail
| LncRNA Name | HOTTIP |
| Synonyms | HOTTIP, HOXA-AS6, HOXA13-AS1, NCRNA00213 |
| Region | GRCh38_7:27198575-27207259 Sequence |
| Ensembl | ENSG00000243766 |
| RefSeq | NR_037843 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qPCR, Luciferase reporter assay, Western blot, etc. |
| Sample | PCa cell lines (DU145, PC-3, LNCaP, 22Rv1). PCa tissues and paired adjacent noncancerous tissues . |
| Expression Pattern | up-regulated |
| Function Description | Above all, knockdown of HOTTIP could represent a rational therapeutic strategy for PCa.Bioinformatics online programs predicted that HOTTIP sponge miR-216a-5p at 3'-UTR with complementary binding sites, which was validated using luciferase reporter assay. HOTTIP could negatively regulate the expression of miR-216a-5p in PCa cells. |
| Pubmed ID | 29884766 |
| Year | 2018 |
| Title | Long non-coding RNA HOTTIP promotes prostate cancer cells proliferation and migration by sponging miR-216a-5p. |
| External Links |
| Links for HOTTIP | GenBank HGNC lncrnadb Noncode |
| Links for prostate cancer | Omim Cosmic |
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