Detail
| LncRNA Name | HOX |
| Synonyms | NA |
| Region | NA Sequence |
| Ensembl | NA |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | glioma |
| ICD-0-3 | M9380/3 |
| Methods | QRT-PCR, in vitro knockdown |
| Sample | glioma tissues, glioma cell lines (U87, LN229 and U251) |
| Expression Pattern | up-regulated |
| Function Description | The expression of HOTAIR and cell viability was found to be lowest in the sh-HOTAIR group among the three groups. The sh-HOTAIR group exhibited a higher apoptotic rate and lower number of cell migration compared with the blank and sh-NC groups. Additionally, the speed of wound healing was slower, the migration distance decreased and the survival time of nude mice was extended in the sh-HOTAIR compared to the other groups. Moreover, the sh-HOTAIR group demonstrated reduced lesion sizes and inflammation, no convulsions or hemiplegia and lesser number of satellite metastases. |
| Pubmed ID | 28857242 |
| Year | 2017 |
| Title | Down-regulation of the long noncoding RNA-HOX transcript antisense intergenic RNA inhibits the occurrence and progression of glioma. |
| External Links |
| Links for HOX | GenBank HGNC lncrnadb Noncode |
| Links for glioma | Omim Cosmic |
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