competing endogenous RNA network analysis inferred that lncRNA ENSG00000240990 competed with HOXA10 to absorb hsa-let-7a/b/f/g-6p and affected patient prognosis in LUAD. Last but not least, by integrating target information of miRNA we also provided a newperspective for the discovery of potential small molecule drugs. In summary, we systematically analyzed the regulatory role of SCNA lncRNAs. This work may facilitate cancer research and serve as the basis for future efforts to understand the role of SCNA lncRNAs, develop novel biomarkers and improve knowledge of tumor biology. We used strict approach to construct ceRNA network. The approach not only considered the lncRNAs/PCGs that acted as miRNA sponges, but also selected negative miRNA-target interactions.