Detail
| LncRNA Name | HOXA11-AS |
| Synonyms | HOXA11-AS, HOXA-AS5, HOXA11-AS1, HOXA11AS, HOXA11S, NCRNA00076 |
| Region | GRCh38_7:27184518-27189293 Sequence |
| Ensembl | ENSG00000240990 |
| RefSeq | NR_002795 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR etc. |
| Sample | cell line (A549) |
| Expression Pattern | up-regulated |
| Function Description | The transfection efficiency was ~100%,and the knockdown efficiency of HOXA11 AS in NSCLC cell lines was >75%, as determined by a reverse transcription quantitative polymerase chain reaction.Following the knockdown of HOXA11-AS,miR-642b-3p was significantly downregulated in A549 NSCLC cells.The ROC curve revealed that the area under curve (AUC) of HOXA11-AS was 0.700 for patients with lung adenocarcinoma and 0.964 for patients with squamous cell carcinoma,which may gain a moderate or high diagnostic value of HOXA11-AS level in lung cancer. |
| Pubmed ID | 29616096 |
| Year | 2018 |
| Title | A comprehensive analysis of the predicted targets of miR-642b-3p associated with the long non-coding RNA HOXA11-AS in NSCLC cells. |
| External Links |
| Links for HOXA11-AS | GenBank HGNC lncrnadb Noncode |
| Links for lung cancer | Omim Cosmic |
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