Detail
| LncRNA Name | HOXA11-AS |
| Synonyms | HOXA11-AS, HOXA-AS5, HOXA11-AS1, HOXA11AS, HOXA11S, NCRNA00076 |
| Region | GRCh38_7:27184518-27189293 Sequence |
| Ensembl | ENSG00000240990 |
| RefSeq | NR_002795 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✔ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, Western blot etc. |
| Sample | ovarian cancer tissues |
| Expression Pattern | down-regulated |
| Function Description | Functional studies of ectopic expression of HOXA11-AS minor allele T in EOC cells showed decreased survival, proliferation, migration, and invasion compared to common allele A expression. Additionally, stable expression of HOXA11-AS minor allele T reduced primary tumor growth in mouse xenograft models to a greater extent than common allele A. Furthermore, HOXA11-AS expression levels were significantly lower in human EOC tumors than normal ovarian tissues, suggesting that HOXA11-AS has a tumor suppressor function in EOC which may be enhanced by the T allele |
| Pubmed ID | 26430965 |
| Year | 2015 |
| Title | A functional variant in HOXA11-AS, a novel long non-coding RNA, inhibits the oncogenic phenotype of epithelial ovarian cancer |
| External Links |
| Links for HOXA11-AS | GenBank HGNC lncrnadb Noncode |
| Links for ovarian cancer | Omim Cosmic |
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