Detail
| LncRNA Name | HOXA11-AS |
| Synonyms | HOXA11-AS, HOXA-AS5, HOXA11-AS1, HOXA11AS, HOXA11S, NCRNA00076 |
| Region | GRCh38_7:27184518-27189293 Sequence |
| Ensembl | ENSG00000240990 |
| RefSeq | NR_002795 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 M8046/3 |
| Methods | qPCR, Western blot etc. |
| Sample | lung tissues, cell lines (A549,H1299, H460) |
| Expression Pattern | up-regulated |
| Function Description | HOXA11-AS expression was upregulated in non-small cell lung cancer tissues and cell lines. High levels of HOXA11-AS expression were correlated with larger tumor size and lymph node metastasis. Functional analysis revealed that HOXA11-AS promotes nonā??small cell lung cancer cell proliferation and invasion. In particular, HOXA11-AS functions as a competing endogenous RNA to regulate transcriptional factor Sp1 expression via sponging miR-124. Collectively, our findings reveal an oncogenic role for HOXA11-AS in nonā??small cell lung cancer tumorigenesis. |
| Pubmed ID | 29034803 |
| Year | 2017 |
| Title | LncRNA HOXA11-AS promotes proliferation and invasion by targeting miR-124 in human nonā??small cell lung cancer cells |
| External Links |
| Links for HOXA11-AS | GenBank HGNC lncrnadb Noncode |
| Links for non small cell lung cancer | Omim Cosmic |
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