Detail
| LncRNA Name | HOXA-AS2 |
| Synonyms | HOXA-AS2, HOXA3as |
| Region | GRCh38_7:27107777-27134302 Sequence |
| Ensembl | ENSG00000253552 |
| RefSeq | NR_122069 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, RNAi, Western blot, RIP, ChIP, Flow cytometry assay, Cell proliferation assay etc. |
| Sample | CRC tissues, cell lines (HCT116, DLD1, SW480, SW620, HT-29 and LOVO) |
| Expression Pattern | up-regulated |
| Function Description | HOXA-AS2 is significantly upregulated in CRC tissue. HOXA-AS2 knockdown significantly suppressed proliferation by blocking the G1/S transition and caused apoptosis of CRC cells in vitro and in vivo. The mechanistic investigations showed that HOXA-AS2 could interact with EZH2, LSD1 and recruit them to p21 (CDKN1A), KLF2 promoter regions to repress their transcription. Furthermore, the rescue experiments demonstrated that HOXA-AS2 oncogenic function is partly through regulating p21. |
| Pubmed ID | 28112720 |
| Year | 2017 |
| Title | Long noncoding RNA HOXA-AS2 represses P21 and KLF2 expression transcription by binding with EZH2, LSD1 in colorectal cancer. |
| External Links |
| Links for HOXA-AS2 | GenBank HGNC lncrnadb Noncode |
| Links for colorectal cancer | Omim Cosmic |
CopyRight © College of Bioinformatics Science and Technology, Harbin Medical University, China.