Detail
| LncRNA Name | HOXD-AS1 |
| Synonyms | HAGLR, HOXD-AS1, Mdgt |
| Region | GRCh38_2:176164051-176188958 Sequence |
| Ensembl | ENSG00000224189 |
| RefSeq | NR_033979 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | neuroblastoma |
| ICD-0-3 | M9500/3 |
| Methods | microarray, qPCR, RNAi, Northern blot etc. |
| Sample | cell line (SH-SY5Y) |
| Expression Pattern | up-regulated |
| Function Description | One of these lncRNAs, termed HOXD-AS1, is encoded in HOXD cluster. HOXD-AS1 is overexpressed in neuroblastoma. We found that HOXD-AS1 is a subjetc to morphogenic regulation, is activated by PI3K/Akt pathway and itself is involved in control of RA-induced cell differentiation. Knock-down experiments revealed that HOXD-AS1 controls expression levels of clinically significant protein-coding genes involved in angiogenesis and inflammation, the hallmarks of metastatic cancer. |
| Pubmed ID | 25522241 |
| Year | 2014 |
| Title | HOXD-AS1 is a novel lncRNA encoded in HOXD cluster and a marker of neuroblastoma progression revealed via integrative analysis of noncoding transcriptome. |
| External Links |
| Links for HOXD-AS1 | GenBank HGNC lncrnadb Noncode |
| Links for neuroblastoma | Omim Cosmic |
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