Detail
| LncRNA Name | HOXD-AS1 |
| Synonyms | HAGLR, HOXD-AS1, Mdgt |
| Region | GRCh38_2:176164051-176188958 Sequence |
| Ensembl | ENSG00000224189 |
| RefSeq | NR_033979 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | melanoma |
| ICD-0-3 | M8720/3 |
| Methods | qPCR, Western blot, RIP |
| Sample | malignant melanoma tissues, cell lines (B16, A375 and A2508, HEMn) |
| Expression Pattern | up-regulated |
| Function Description | lncRNA HOXD-AS1 expression was remarkably higher in melanoma tissues. Increased expression of lncRNA HOXD-AS1 correlated with poor survival of melanoma patients.upregulated lncRNA HOXD-AS1 expression dramatically promoted cell proliferation and invasion of melanoma. lncRNA HOXD-AS1 knockdown notably reduced tumor growth.lncRNA HOXD-AS1 could epigenetically suppress the expression of RUNX3 via binding to EZH2. Downregulation of RUNX3 attenuated the proliferation and invasion-inhibiting effects induced by lncRNA HOXD-AS1 knockdown in melanoma cells. |
| Pubmed ID | 29312805 |
| Year | 2017 |
| Title | LncRNA HOXD-AS1 promotes melanoma cell proliferation and invasion by suppressing RUNX3 expression. |
| External Links |
| Links for HOXD-AS1 | GenBank HGNC lncrnadb Noncode |
| Links for melanoma | Omim Cosmic |
CopyRight © College of Bioinformatics Science and Technology, Harbin Medical University, China.