Detail
| LncRNA Name | HOXD-AS1 |
| Synonyms | HAGLR, HOXD-AS1, Mdgt |
| Region | GRCh38_2:176164051-176188958 Sequence |
| Ensembl | ENSG00000224189 |
| RefSeq | NR_033979 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | epithelial ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, Luciferase reporter assay, Western blot |
| Sample | epithelial ovarian cancer tissues, cell lines (SKOV3, HO8910, ES-2, and CAOV3, IOSE80) |
| Expression Pattern | up-regulated |
| Function Description | the expression of HOXD-AS1 was upregulated in EOC tissues and cell lines. High HOXD-AS1 expression was correlated with advanced FIGO stage, lymph node metastasis, and poor overall survival in EOC patients. HOXD-AS1 promoted cell proliferation, invasion, and epithelial-mesenchymal transition (EMT) via activating Wnt/B-catenin signaling in EOC cells.miR-133a-3p was a direct downstream target of HOXD-AS1 in EOC. HOXD-AS1 promoted cell proliferation, invasion, and EMT process through sponging miR-133a-3p in EOC cells. |
| Pubmed ID | 29239819 |
| Year | 2017 |
| Title | LncRNA HOXD-AS1 promotes epithelial ovarian cancer cells proliferation and invasion by targeting miR-133a-3p and activating Wnt/B-catenin signaling pathway. |
| External Links |
| Links for HOXD-AS1 | GenBank HGNC lncrnadb Noncode |
| Links for epithelial ovarian cancer | Omim Cosmic |
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