Detail
| LncRNA Name | HSP90AA1-IT1 |
| Synonyms | NA |
| Region | NA Sequence |
| Ensembl | NA |
| RefSeq | NA |
| Circulating | ✔ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✔ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | glioma |
| ICD-0-3 | M9380/3 |
| Methods | qPCR, Western blot, Luciferase reporter assay, Luciferase reporter assay |
| Sample | brain tissue |
| Expression Pattern | down-regulated |
| Function Description | Taken together, it is concluded that HSP90AA1-IT1, performs its function via regulating the development of gliomas through miR-885-5p-CDK2 signaling axis, and this has added new perspective to its role in tumorigenesis, thus providing potential therapeutic targets for glioma treatment.Curve graph indicated survival time of the xenograft mice. A dual-luciferase reporter vector was used to generate the luciferase constructs. The putative binding sites and its homologous mutation sites in the 3â??-UTR region of CDK2 mRNA and HSP90AA1-IT1 were amplified and cloned into pmiRGLO luciferase reporter plasmid. |
| Pubmed ID | 29088865 |
| Year | 2017 |
| Title | LncRNA HSP90AA1-IT1 promotes gliomas by targeting miR-885-5p-CDK2 pathway. |
| External Links |
| Links for HSP90AA1-IT1 | GenBank HGNC lncrnadb Noncode |
| Links for glioma | Omim Cosmic |
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