Detail
| LncRNA Name | HULC |
| Synonyms | HULC, HCCAT1, LINC00078, NCRNA00078 |
| Region | GRCh38_6:8435568-9294133 Sequence |
| Ensembl | ENSG00000251164 |
| RefSeq | NR_004855 |
| Circulating | ✔ |
| Drug-resisitant | ✔ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, drugs sensitivity |
| Sample | Plasma, gastric adenocarcinoma cell lines (MGC-803 and MKN-45) |
| Expression Pattern | up-regulated |
| Function Description | HULC was highly expressed in the plasma and tissues of the GC patients compared with controls, with HULC high expression indicating lower survival rate. HULC knockdown enhanced cisplatin-induced apoptosis in GC cells.We observed that HULC knockdown in both MGC-803 and MKN-45 cells significantly decreased the IC50 values of CDDP, ADR, and 5-FU |
| Pubmed ID | 28356873 |
| Year | 2016 |
| Title | Silencing of LncRNA HULC Enhances Chemotherapy Induced Apoptosis in Human Gastric Cancer |
| External Links |
| Links for HULC | GenBank HGNC lncrnadb Noncode |
| Links for gastric cancer | Omim Cosmic |
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