Detail
| LncRNA Name | HULC |
| Synonyms | HULC, HCCAT1, LINC00078, NCRNA00078 |
| Region | GRCh38_6:8435568-9294133 Sequence |
| Ensembl | ENSG00000251164 |
| RefSeq | NR_004855 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | osteosarcoma |
| ICD-0-3 | M9180/3 |
| Methods | qPCR, Luciferase reporter assay, Western blot |
| Sample | cell lines (MG63, hFOB1.19, OS-732) |
| Expression Pattern | up-regulated |
| Function Description | Suppression of HULC in osteosarcoma cells inhibited cell viability,migration,invasion, and promoted apoptosis. HULC functioned as an endogenous sponge for miR-122,and its silence functioned through upregulating miR-122.Furthermore,overexpression of miR-122 inactivated PI3K/AKT, JAK/STAT, and Notch pathways by downregulation of HNF4G. high levels of HULC were associated with low survival rates in osteosarcoma patients. |
| Pubmed ID | 28688193 |
| Year | 2017 |
| Title | Knockdown of lncRNA HULC inhibits proliferation, migration, invasion, and promotes apoptosis by sponging miR-122 in osteosarcoma. |
| External Links |
| Links for HULC | GenBank HGNC lncrnadb Noncode |
| Links for osteosarcoma | Omim Cosmic |
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