Lnc2Cancer

Experimentally Supported Human LncRNA and Cancer Associations Database

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   LncRNA Name HULC
   Synonyms HULC, HCCAT1, LINC00078, NCRNA00078
   Region GRCh38_6:8435568-9294133    Sequence
   Ensembl ENSG00000251164
   RefSeq NR_004855
   Circulating
   Drug-resisitant
   Prognostic
   MiRNA
   Variant
   TF
   Methylation
   Cancer Name liver cancer
   ICD-0-3 C22.0  
   Methods qPCR, Western blot, Luciferase reporter assay etc.
   Sample liver cancer tissues, cell lines (CREB, HULC, Prkacb etc.)
   Expression Pattern up-regulated
   Function Description

The study elucidates that fine tuning of HULC expression is part of an auto-regulatory loop in which it's inhibitory to expression and activity of miR-372 allows lncRNA up-regulated expression in liver cancer.

   Pubmed ID 20423907
   Year 2010
   Title CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer.
   External Links
   Links for  HULC GenBank       HGNC       lncrnadb       Noncode
   Links for  liver cancer Omim       Cosmic

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