Detail
| LncRNA Name | HULC |
| Synonyms | HULC, HCCAT1, LINC00078, NCRNA00078 |
| Region | GRCh38_6:8435568-9294133 Sequence |
| Ensembl | ENSG00000251164 |
| RefSeq | NR_004855 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✔ |
| Methylation | ✘ |
| Cancer Name | liver cancer |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, Luciferase reporter assay etc. |
| Sample | hepatocarcinoma cell lines (HepG2, Huh7, HepG2.2.15 ), hepatocarcinoma tissues |
| Expression Pattern | up-regulated |
| Function Description | Interestingly, we also observed that HULC could up-regulate HMGA2 in HCC cells. Mechanistically, we found that the microRNA-186 inhibited HMGA2 expression by targeting the 3'-untranslated region (3'-UTR) of HMGA2 mRNA. Strikingly, HULC acted as a competing noncoding RNA to sequester miR-186 and thereby relieved miR-186-mediated HMGA2 repression. Previously, our group reported that HULC could be up-regulated by hepatitis B virus X protein (HBx) through transcription factor CREB. HULC interacted with the 5-untranslated region (5-UTR) of CLOCK mRNA via complementary base pairing, resulting in the elevation of CLOCK expression. |
| Pubmed ID | 28765279 |
| Year | 2017 |
| Title | The long noncoding RNA HULC promotes liver cancer by increasing the expression of the HMGA2 oncogene via sequestration of the microRNA-186. |
| External Links |
| Links for HULC | GenBank HGNC lncrnadb Noncode |
| Links for liver cancer | Omim Cosmic |
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