Detail
| LncRNA Name | HULC |
| Synonyms | HULC, HCCAT1, LINC00078, NCRNA00078 |
| Region | GRCh38_6:8435568-9294133 Sequence |
| Ensembl | ENSG00000251164 |
| RefSeq | NR_004855 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 M8170/3 |
| Methods | qPCR, Western blot, RIP etc. |
| Sample | cell lines (HepG2, Hep3B) |
| Expression Pattern | up-regulated |
| Function Description | HULC promoted the growth of HCC cells through elevating COX-2 protein. knockdown of USP22 or COX-2 attenuated HULC-mediated abnormal growth of HCC cells.HULC promoted the survival of HepG2 and Hep3B cells in a dosedependent manner.We previous revealed that three miRNAs (miR-6825e5p, miR-6845e5p and miR-6886e3p) were involved in HULC mediated USP22 and Sirt1 upregulation |
| Pubmed ID | 28634076 |
| Year | 2017 |
| Title | lncRNA HULC promotes the growth of hepatocellular carcinoma cells via stabilizing COX-2 protein. |
| External Links |
| Links for HULC | GenBank HGNC lncrnadb Noncode |
| Links for hepatocellular carcinoma | Omim Cosmic |
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