Detail
| LncRNA Name | HULC |
| Synonyms | HULC, HCCAT1, LINC00078, NCRNA00078 |
| Region | GRCh38_6:8435568-9294133 Sequence |
| Ensembl | ENSG00000251164 |
| RefSeq | NR_004855 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✔ |
| Methylation | ✘ |
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 M8170/3 |
| Methods | qPCR, RNAi, Western blot, Cell proliferation assay etc. |
| Sample | cell lines (HepG2, SNU-449, and SK-Hep-1) |
| Expression Pattern | up-regulated |
| Function Description | Sp1, Sp3 and Sp4 transcription factors regulate HULC and other lncRNAs in HCC cells. Sp proteins and HULC regulate HCC cell proliferation, survival, migration/invasion. Knockdown of Sp1 and HULC inhibit HCC cancer cell migration and invasion |
| Pubmed ID | 26317792 |
| Year | 2015 |
| Title | Specificity protein (Sp) transcription factors and metformin regulate expression of the long non-coding RNA HULC. |
| External Links |
| Links for HULC | GenBank HGNC lncrnadb Noncode |
| Links for hepatocellular carcinoma | Omim Cosmic |
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