Detail
| LncRNA Name | HULC |
| Synonyms | HULC, HCCAT1, LINC00078, NCRNA00078 |
| Region | GRCh38_6:8435568-9294133 Sequence |
| Ensembl | ENSG00000251164 |
| RefSeq | NR_004855 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 M8170/3 |
| Methods | qPCR, RNAi, Western blot, Luciferase reporter assay etc. |
| Sample | HCC tissues, cell lines (HepG2, Hep3B, PLC, Huh7, smmc7721 and L02) |
| Expression Pattern | up-regulated |
| Function Description | Silencing of HULC sensitized HCC cells to the three antitumor reagents via inhibiting protective autophagy. Ectopic expression of HULC elicited the autophagy of HCC cells through stabilizing silent information regulator 1 (Sirt1) protein. In addition, we showed that the level of HULC was positively correlated with that of Sirt1 protein in human HCC tissues. Collectively, our data reveals that the pathway 'HULC/USP22/Sirt1/ protective autophagy' attenuates the sensitivity of HCC cells to chemotherapeutic agents. |
| Pubmed ID | 28166203 |
| Year | 2017 |
| Title | LncRNA HULC triggers autophagy via stabilizing Sirt1 and attenuates the chemosensitivity of HCC cells. |
| External Links |
| Links for HULC | GenBank HGNC lncrnadb Noncode |
| Links for hepatocellular carcinoma | Omim Cosmic |
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