Detail
| LncRNA Name | ILF3-AS1 |
| Synonyms | XLOC_013222 |
| Region | GRCh38_19:10651862-10653844 Sequence |
| Ensembl | ENSG00000267100 |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | melanoma |
| ICD-0-3 | M8720/3 |
| Methods | qPCR, RIP etc. |
| Sample | breast cancer tissues, non-small cell lung cancer tissues |
| Expression Pattern | up-regulated |
| Function Description | lncRNA ILF3-AS1 is upregulated in melanoma tissues and cell lines, and correlated with poor prognosis of melanoma patients. Functional experiments showed that knockdown of ILF3-AS1 inhibits melanoma cell proliferation, migration and invasion. Mechanistically, we found that ILF3-AS1 interacts with EZH2, promotes the binding of EZH2 to the miR-200b/a/429 promoter, and represses miR-200b/a/429 expression. The expression of ILF3-AS1 is negatively correlated with that of miR-200b/a/429 in melanoma tissues.Moreover,inhibition of miR-200b/a/429 abrogates the biological roles of ILF3-AS1 knockdown on melanoma cell proliferation, migration and invasion. |
| Pubmed ID | 28935763 |
| Year | 2017 |
| Title | Long noncoding RNA ILF3-AS1 promotes cell proliferation, migration and invasion via negatively regulating miR-200b/a/429 in melanoma |
| External Links |
| Links for ILF3-AS1 | GenBank HGNC lncrnadb Noncode |
| Links for melanoma | Omim Cosmic |
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