Detail
| LncRNA Name | KCNQ1OT1 |
| Synonyms | KCNQ1OT1, KCNQ1-AS2, Kncq1, KvDMR1, KvLQT1-AS, LIT1, NCRNA00012 |
| Region | GRCh38_11:2608328-2699994 Sequence |
| Ensembl | ENSG00000269821 |
| RefSeq | NR_002728 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | melanoma |
| ICD-0-3 | M8720/3 |
| Methods | Microarray, qPCR, Western blot etc. |
| Sample | melanoma tissues, cell lines (HACAT, A375, A875 and MuM-2C) |
| Expression Pattern | up-regulated |
| Function Description | KCNQ1OT1 expression is up-regulated in melanoma tissues and cells.KCNQ1OT1 promoted cell proliferation and metastasis in melanoma.By directly bindin to miR-153,KCNQ1OT1 acted as a competing endogenous RNA (ceRNA) to de-repress MET expression. |
| Pubmed ID | 29667930 |
| Year | 2018 |
| Title | KCNQ1OT1 promotes melanoma growth and metastasis. |
| External Links |
| Links for KCNQ1OT1 | GenBank HGNC lncrnadb Noncode |
| Links for melanoma | Omim Cosmic |
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