Lnc2Cancer

Experimentally Supported Human LncRNA and Cancer Associations Database

LncRNA centric

Cancer centric

Advanced search

Drug resistant

Circulating

Prognosis

Detail


   LncRNA Name KCNQ1OT1
   Synonyms KCNQ1OT1, KCNQ1-AS2, Kncq1, KvDMR1, KvLQT1-AS, LIT1, NCRNA00012
   Region GRCh38_11:2608328-2699994    Sequence
   Ensembl ENSG00000269821
   RefSeq NR_002728
   Circulating
   Drug-resisitant
   Prognostic
   MiRNA
   Variant
   TF
   Methylation
   Cancer Name colorectal cancer
   ICD-0-3 C19.9  
   Methods qPCR, RNAi, Western blot, ChIP, Luciferase reporter assay, RNA-FISH etc.
   Sample cell lines (HCT116, DLD-1, HCT15, SW480 and HEK293)
   Expression Pattern up-regulated
   Function Description

Here, we show that the KCNQ1OT1 transcriptional level was significantly increased in human colorectal cancer cells in which B-catenin was excessively accumulated in the nucleus. Additionally, overexpression of B-catenin resulted in an increase in KCNQ1OT1 lncRNA-coated territory. On the other hand, knockdown of B-catenin resulted in significant decrease of KCNQ1OT1 lncRNA-coated territory and an increase in the mRNA expression of the SLC22A18 and PHLDA2 genes that are regulated by KCNQ1OT1. We showed that B-catenin can promote KCNQ1OT1 transcription through direct binding to the KCNQ1OT1 promoter.

   Pubmed ID 26868975
   Year 2016
   Title Regulation of functional KCNQ1OT1 lncRNA by B-catenin.
   External Links
   Links for  KCNQ1OT1 GenBank       HGNC       lncrnadb       Noncode
   Links for  colorectal cancer Omim       Cosmic

CopyRight © College of Bioinformatics Science and Technology, Harbin Medical University, China.