Detail
LncRNA Name | KCNQ1OT1 |
Synonyms | KCNQ1OT1, KCNQ1-AS2, Kncq1, KvDMR1, KvLQT1-AS, LIT1, NCRNA00012 |
Region | GRCh38_11:2608328-2699994 Sequence |
Ensembl | ENSG00000269821 |
RefSeq | NR_002728 |
Circulating | ✘ |
Drug-resisitant | ✘ |
Prognostic | ✘ |
MiRNA | ✘ |
Variant | ✘ |
TF | ✘ |
Methylation | ✘ |
Cancer Name | colorectal cancer |
ICD-0-3 | C19.9 |
Methods | qPCR, RNAi, Western blot, ChIP, Luciferase reporter assay, RNA-FISH etc. |
Sample | cell lines (HCT116, DLD-1, HCT15, SW480 and HEK293) |
Expression Pattern | up-regulated |
Function Description | Here, we show that the KCNQ1OT1 transcriptional level was significantly increased in human colorectal cancer cells in which B-catenin was excessively accumulated in the nucleus. Additionally, overexpression of B-catenin resulted in an increase in KCNQ1OT1 lncRNA-coated territory. On the other hand, knockdown of B-catenin resulted in significant decrease of KCNQ1OT1 lncRNA-coated territory and an increase in the mRNA expression of the SLC22A18 and PHLDA2 genes that are regulated by KCNQ1OT1. We showed that B-catenin can promote KCNQ1OT1 transcription through direct binding to the KCNQ1OT1 promoter. |
Pubmed ID | 26868975 |
Year | 2016 |
Title | Regulation of functional KCNQ1OT1 lncRNA by B-catenin. |
External Links |
Links for KCNQ1OT1 | GenBank HGNC lncrnadb Noncode |
Links for colorectal cancer | Omim Cosmic |
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