Detail
| LncRNA Name | KCNQ1OT1 |
| Synonyms | KCNQ1OT1, KCNQ1-AS2, Kncq1, KvDMR1, KvLQT1-AS, LIT1, NCRNA00012 |
| Region | GRCh38_11:2608328-2699994 Sequence |
| Ensembl | ENSG00000269821 |
| RefSeq | NR_002728 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | RNA-seq, microarray, qPCR, RNAi, Northern blot etc. |
| Sample | prostate cancer tissues, cell lines (LNCaP, CWR22Rv1, PC3 etc.) |
| Expression Pattern | up-regulated |
| Function Description | Interestingly, nine out of these thirteen known cancer-related lncRNA showed significantly differential expression between tumor and normal prostate samples. Several lncRNA such as NEAT1, DANCR, HOTTIP, PRINS, and EGOT that have established functions in forming nuclear speckles, in development or in autoimmune disease, but were not previously known to be related to cancer, showed differential expression between tumor and normal prostate samples, suggesting their potential function in prostate cancer. |
| Pubmed ID | 23728290 |
| Year | 2013 |
| Title | Integrative genomic analyses reveal clinically relevant long noncoding RNAs in human cancer. |
| External Links |
| Links for KCNQ1OT1 | GenBank HGNC lncrnadb Noncode |
| Links for prostate cancer | Omim Cosmic |
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