Detail
| LncRNA Name | KCNQ1OT1 |
| Synonyms | KCNQ1OT1, KCNQ1-AS2, Kncq1, KvDMR1, KvLQT1-AS, LIT1, NCRNA00012 |
| Region | GRCh38_11:2608328-2699994 Sequence |
| Ensembl | ENSG00000269821 |
| RefSeq | NR_002728 |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✔ |
| Cancer Name | hypopharyngeal squamous cell carcinoma |
| ICD-0-3 | C13 M8070/3 |
| Methods | Microarray,qPCR,Western blot,Cell proliferation assay,Luciferase reporter assay,RIP,etc. |
| Sample | TSCC samples and cell lines(CAL27,SCC9),normal tissues,chemo-sensitive samples and chemo-insensitive TSCC tissues. |
| Expression Pattern | up-regulated |
| Function Description | Finally, miR-211-5p inhibition in sh-KCNQ1OT1-expressing TSCC cells rescued the suppressed cell proliferation and cisplatin resistance induced by KCNQ1OT1 knockdown. In summary, our study has elucidated the role of the oncogenic lncRNA KCNQ1OT1 in TSCC growth and chemo-resistance, which may serve as a new target for TSCC therapy.he stable cisplatin-resistant cell lines, CAL27-res and SCC9-res, were established by the selection of CAL27 or SCC9 colonies treated with 10?7 to 10?5?M cisplatin (Sigma, Carlsbad, CA, USA) as described previously.Kaplan-Meier survival analysis indicated that increased KCNQ1OT1 expression in TSCC tissues was significantly associated with a lower rate of overall survival (p? |
| Pubmed ID | 29970910 |
| Year | 2018 |
| Title | LncRNA KCNQ1OT1 regulates proliferation and cisplatin resistance in tongue cancer via miR-211-5p mediated Ezrin/Fak/Src signaling. |
| External Links |
| Links for KCNQ1OT1 | GenBank HGNC lncrnadb Noncode |
| Links for hypopharyngeal squamous cell carcinoma | Omim Cosmic |
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