Detail
| LncRNA Name | LCAL1 |
| Synonyms | LCAL1, onco-lncRNA-27 |
| Region | NA Sequence |
| Ensembl | NA |
| RefSeq | NR_130915 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✔ |
| TF | ✔ |
| Methylation | ✘ |
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | RNA-seq, qPCR, RNAi etc. |
| Sample | lung cancer tissues |
| Expression Pattern | up-regulated |
| Function Description | Stable overexpression of LCAL1, using two different clones, in the control cell line BEAS-2B showed a significant increase in cellular proliferation starting on day 2 and continuing until the end of the experiment at day 6 with a 38% and 43% growth increase, respetcively. Overexpression of LCAL1 in normal BEAS-2B cells is proof of principle that this lncRNA is sufficient to affetc cellular growth independently of other common cancer mutations, thus highlighting the importance of LCAL1 in lung cancer biology. |
| Pubmed ID | 25116943 |
| Year | 2014 |
| Title | Transcriptome sequencing reveals altered long intergenic non-coding RNAs in lung cancer. |
| External Links |
| Links for LCAL1 | GenBank HGNC lncrnadb Noncode |
| Links for lung cancer | Omim Cosmic |
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