Detail
| LncRNA Name | LeXis |
| Synonyms | NA |
| Region | NA Sequence |
| Ensembl | NA |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | osteosarcoma |
| ICD-0-3 | M9180/3 |
| Methods | qPCR, Western blot etc. |
| Sample | OS tissues, cell lines (Nhost, KHOS, 143b, LM7, U2OS, and MG-63) |
| Expression Pattern | up-regulated |
| Function Description | LeXis expression was upregulated in OS tissues. Increased LeXis expression was significantly correlated with high tumor stage, large tumor size, and poor prognosis. LeXis increased CTNNB1 expression by functioning as a ceRNA of CTNNB1 against miR-199a.Moreover, LeXis increased CTNNB1 expression by functioning as a ceRNA of CTNNB1 against miR-199a. The 5-year survival rate of patients with OS having distant metastases is approximately 30% . |
| Pubmed ID | 28744406 |
| Year | 2017 |
| Title | Long noncoding RNA LeXis promotes osteosarcoma growth through upregulation of CTNNB1 expression. |
| External Links |
| Links for LeXis | GenBank HGNC lncrnadb Noncode |
| Links for osteosarcoma | Omim Cosmic |
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