Detail
| LncRNA Name | LINC00052 |
| Synonyms | LINC00052, NCRNA00052, TMEM83, FLJ31461 |
| Region | GRCh38_15:87576929-87579866 Sequence |
| Ensembl | ENSG00000259527 |
| RefSeq | NR_026869 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 M8170/3 |
| Methods | qPCR, Western blot, RIP etc, |
| Sample | hepatocellular carcinoma tissues, cell lines (L02, SMMC7721, SK-hep1, Huh7, HepG2) |
| Expression Pattern | up-regulated |
| Function Description | We found that overexpression of LINC00052 could upregulate the EPB41L3 expression and it might serve as a tumor suppressor gene in HCC. Database analysis showed that miR-452-5P could target LINC00052. The binding regions between LINC00052 and miR-452-5P were confirmed by luciferase assays. Moreover, LINC00052 inhibited cell malignant behavior by increasing miR-452-5P expression, suggesting that LINC00052 was negatively regulated by miR-452-5P.In addition, overexpression of miR-452-5P resulted in a decrease of EPB41L3 expression, suggesting that EPB41L3 was as a target of miR-452-5P. In conclusion, these results demonstrated that a novel pathway was mediated by LINC00052 in HCC. |
| Pubmed ID | 28969024 |
| Year | 2017 |
| Title | LINC00052 upregulates EPB41L3 to inhibit migration and invasion of hepatocellular carcinoma by binding miR-452-5p. |
| External Links |
| Links for LINC00052 | GenBank HGNC lncrnadb Noncode |
| Links for hepatocellular carcinoma | Omim Cosmic |
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