Detail
| LncRNA Name | LINC00092 |
| Synonyms | LINC00092, NCRNA00092, bA346B7.1 |
| Region | GRCh38_9:96019732-96027965 Sequence |
| Ensembl | ENSG00000225194 |
| RefSeq | NR_024129 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | microarray, qPCR, RNAi, RNA pull-down assay etc. |
| Sample | ovarian cancer tissues, cell lines (SKOV-3 and A2780) |
| Expression Pattern | up-regulated |
| Function Description | CXCL14-high CAFs mediated upregulation of LINC00092 in ovarian cancer cells, the levels of which also correlated with poor prognosis in patients. Mechanistic studies showed that LINC00092 bound a glycolytic enzyme, the fructose-2,6-biphosphatase PFKFB2, thereby promoting metastasis by altering glycolysis and sustaining the local supportive function of CAFs. |
| Pubmed ID | 28087599 |
| Year | 2017 |
| Title | Long Noncoding RNA LINC00092 Acts in Cancer-Associated Fibroblasts to Drive Glycolysis and Progression of Ovarian Cancer. |
| External Links |
| Links for LINC00092 | GenBank HGNC lncrnadb Noncode |
| Links for ovarian cancer | Omim Cosmic |
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