Detail
| LncRNA Name | LINC00152 |
| Synonyms | CYTOR, C2orf59, LINC00152, NCRNA00152, MGC4677 |
| Region | GRCh38_2:87454781-87636740 Sequence |
| Ensembl | ENSG00000222041 |
| RefSeq | NR_024204 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 M8170/3 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown etc. |
| Sample | cell lines (SMMC-7721, Hep3B, HCCLM3 and HepG2), HCC tissues |
| Expression Pattern | down-regulated |
| Function Description | The results indicated that the expression level of LINC00152 was positively correlated with tumor size (OR=5.19, 95% CI: 2.33-11.52, p<.0001), TNM stage (OR=3.12, 95% CI: 1.77-5.51, p<.0001) and lymph node metastasis (OR=3.41, 95% CI: 2.13-5.48, p<.00001). Moreover, elevated LINC00152 could predict unfavorable OS with pooled HR of 1.66 (95% CI: 1.29-2.13, p<.0001) and poor DFS (HR=2.13, 95% CI: 1.39-3.25, p=.0005) in cancer patients. CONCLUSION: LINC00152 was correlated with advanced clinicopathological features and poor prognosis as a novel predictive biomarker in various cancers. |
| Pubmed ID | 29617624 |
| Year | 2018 |
| Title | Long noncoding RNA LINC00152 as a novel predictor of lymph node metastasis and survival in human cancer: a systematic review and meta-analysis. |
| External Links |
| Links for LINC00152 | GenBank HGNC lncrnadb Noncode |
| Links for hepatocellular carcinoma | Omim Cosmic |
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