Lnc2Cancer

Experimentally Supported Human LncRNA and Cancer Associations Database

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   LncRNA Name LINC00152
   Synonyms CYTOR, C2orf59, LINC00152, NCRNA00152, MGC4677
   Region GRCh38_2:87454781-87636740    Sequence
   Ensembl ENSG00000222041
   RefSeq NR_024204
   Circulating
   Drug-resisitant
   Prognostic
   MiRNA
   Variant
   TF
   Methylation
   Cancer Name glioblastoma
   ICD-0-3 C22.0  M8170/3
   Methods qPCR, Western blot analysis, RNA-seq
   Sample U87 cells, brain tumors and normal brain tissue
   Expression Pattern up-regulated
   Function Description

LINC00152/CYTOR is upregulated in glioblastoma multiforme (GBM) and aggressive wild-type IDH1/2 grade II/III gliomas and upregulation associates with poor patient outcomes.LINC00152 and its homolog MIR4435-2HG associate with aggressive tumors and promote cellular invasion through a mechanism that requires the structural integrity of a hairpin structure.

   Pubmed ID 29991527
   Year 2018
   Title LINC00152 Promotes Invasion Through a 3'-hairpin Structure and Associates with Prognosis in Glioblastoma.
   External Links
   Links for  LINC00152 GenBank       HGNC       lncrnadb       Noncode
   Links for  glioblastoma Omim       Cosmic

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