Detail
| LncRNA Name | LINC00161 |
| Synonyms | LINC00161, C21orf100 |
| Region | GRCh38_21:28539318-28540355 Sequence |
| Ensembl | ENSG00000226935 |
| RefSeq | NR_026552 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | osteosarcoma |
| ICD-0-3 | M9180/3 |
| Methods | microarray, qPCR, RNAi, RIP, Dual-luciferase reporter assay etc. |
| Sample | cell lines (MG-63 and U2OS) |
| Expression Pattern | up-regulated |
| Function Description | Here, we found that lncRNA LINC00161 was induced by cisplatin in osteosarcoma cells. Elevated LINC00161 increased cisplatin-induced apoptosis and reversed the cisplatin-resistant phenotype of osteosarcoma cells by upregulating IFIT2. Further mechanistic studies revealed that LINC00161 could sponge endogenous miR-645 and inhibit its activity leading to IFIT2 increase. In addition, we identified that LINC00161 enhanced cisplatin-induced apoptosis through regulation of the miR-645-IFIT2 pathway. |
| Pubmed ID | 27609068 |
| Year | 2016 |
| Title | Long non-coding RNA LINC00161 sensitises osteosarcoma cells to cisplatin-induced apoptosis by regulating the miR-645-IFIT2 axis. |
| External Links |
| Links for LINC00161 | GenBank HGNC lncrnadb Noncode |
| Links for osteosarcoma | Omim Cosmic |
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