Detail
| LncRNA Name | ANRIL |
| Synonyms | CDKN2B-AS1, ANRIL, CDKN2B-AS, CDKN2BAS, NCRNA00089, PCAT12, p15AS |
| Region | GRCh38_9:21994778-22121097 Sequence |
| Ensembl | ENSG00000240498 |
| RefSeq | NR_003529 |
| Circulating | ✔ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✔ |
| TF | ✘ |
| Methylation | ✔ |
| Cancer Name | neurofibromatosis type 1 |
| ICD-0-3 | M9540/1 |
| Methods | microarray, qPCR etc. |
| Sample | blood |
| Expression Pattern | up-regulated |
| Function Description | Single-nucleotide polymorphism rs2151280 (located in ANRIL) was statistically significantly associated with the number of PNFs in NF1 patients. In addition, allele T of rs2151280 was statistically significantly associated with reduced ANRIL transcript levels, suggesting that modulation of ANRIL expression mediates PNF susceptibility. Identification of ANRIL as a modifier gene in NF1 may offer clues to the molecular pathogenesis of PNFs, particularly neurofibroma formation, and emphasizes the unanticipated role of large noncoding RNA in activation of critical regulators of tumor development. |
| Pubmed ID | 22034633 |
| Year | 2011 |
| Title | Role of noncoding RNA ANRIL in genesis of plexiform neurofibromas in neurofibromatosis type 1. |
| External Links |
| Links for ANRIL | GenBank HGNC lncrnadb Noncode |
| Links for neurofibromatosis type 1 | Omim Cosmic |
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