Lnc2Cancer

Experimentally Supported Human LncRNA and Cancer Associations Database

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   LncRNA Name LINC00339
   Synonyms LINC00339, HSPC157, NCRNA00339
   Region GRCh38_1:22024558-22031223    Sequence
   Ensembl ENSG00000218510
   RefSeq NR_023918
   Circulating
   Drug-resisitant
   Prognostic
   MiRNA
   Variant
   TF
   Methylation
   Cancer Name glioma
   ICD-0-3  M9380/3
   Methods qPCR, Western blot, Luciferase reporter assay etc.
   Sample cell lines (U87,U251), glioma tissues
   Expression Pattern up-regulated
   Function Description

Knockdown of LINC00339 inhibited glioma cell proliferation, migration, invasion, and tube formation,meanwhile downregulating the expression of VM-related molecular MMP-2 and MMP-14.TWIST1 upregulated the promoter activities of MMP-2 and MMP-14.

   Pubmed ID 29499931
   Year 2017
   Title Long Non-coding RNA LINC00339 Stimulates Glioma Vasculogenic Mimicry Formation by Regulating the miR-539-5p/TWIST1/MMPs Axis.
   External Links
   Links for  LINC00339 GenBank       HGNC       lncrnadb       Noncode
   Links for  glioma Omim       Cosmic

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