Detail
| LncRNA Name | LINC00462 |
| Synonyms | NA |
| Region | GRCh38_13:48576974-48578088 Sequence |
| Ensembl | ENSG00000233610 |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | qPCR, Western blot, etc. |
| Sample | pancreatic cancer tissues, cell lines (SW1990, BxPC-3, PANC-1, AsPC-1, CFPAC-1, HPDE6-C7ï¼? |
| Expression Pattern | up-regulated |
| Function Description | we demonstrated that linc00462 was a target of miR-665. Linc00462 overexpression enhanced the expression levels of TGFBR1 and TGFBR2, and thus activated the SMAD2/3 pathway in PC cells. We demonstrated that OSM mediated up-regulation of linc00462 promoted cell proliferation by accelerating cell cycle process and inhibiting cell apoptosis and adhesion in vitro, enhanced cell migration and invasion by accelerating EMT process, promoted tumor growth and matastasis in vivo and was associated with large tumor size, poor tumor differentiation, TNM stage and distant metastasis in patients of PC. |
| Pubmed ID | 29899418 |
| Year | 2018 |
| Title | Linc00462 promotes pancreatic cancer invasiveness through the miR-665/TGFBR1-TGFBR2/SMAD2/3 pathway. |
| External Links |
| Links for LINC00462 | GenBank HGNC lncrnadb Noncode |
| Links for pancreatic cancer | Omim Cosmic |
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