Detail
| LncRNA Name | Linc00518 |
| Synonyms | C6orf218, MGC40222 |
| Region | GRCh38_6:10429255-10434874 Sequence |
| Ensembl | ENSG00000183674 |
| RefSeq | NR_027793 |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✔ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | breast cancer |
| ICD-0-3 | C76.0 |
| Methods | qRT-PCR, Western blot assays, Luciferase reporter assays, RIP |
| Sample | Human mammary epithelial cell line (MCF-10A) and human breast cancer cell line (MCF-7), The ADR-resistant variant (MCF-7/ADR) cell line, breast cancer tissue specimens and the adjacent normal tissues |
| Expression Pattern | up-regulated |
| Function Description | linc00518 expression increased nearly 2 fold and MRP1 level elevated about 2.5 fold in breast cancer tissues as compared to that in adjacent normal tissues. miR-199a inhibitor conferred chemoresistance to ADR, VCR and PTX in MCF-7/ADR cells, and suppressing miR-199a reversed multi-drug susceptibility induced by linc00518 knockdown. Furthermore, linc00518 could act as a molecular sponge of miR-199a to repress MRP1 expression. MRP1 depletion increased the sensitivity of MCF-7/ADR cells to ADR, VCR and PTX, and this effect was attenuated following miR-199a inhibition or linc00518 |
| Pubmed ID | 30001527 |
| Year | 2018 |
| Title | Linc00518 Contributes to Multidrug Resistance Through Regulating the MiR-199a/MRP1 Axis in Breast Cancer. |
| External Links |
| Links for Linc00518 | GenBank HGNC lncrnadb Noncode |
| Links for breast cancer | Omim Cosmic |
CopyRight © College of Bioinformatics Science and Technology, Harbin Medical University, China.