Detail
| LncRNA Name | LINC00668 |
| Synonyms | NA |
| Region | GRCh38_18:6919496-6929966 Sequence |
| Ensembl | ENSG00000265933 |
| RefSeq | NR_034100 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | oral squamous cell carcinoma |
| ICD-0-3 | C06.9 M8070/3 |
| Methods | RNAi, Western blot, qPCR, Luciferase reporter assays, RNA pull-down assays |
| Sample | OSCC tissues, cell lines (SCC4, SCC9, SCC1, SCC25, TU183, HSU3, FADU, OEC-M1, SNU1041, and SCC15) |
| Expression Pattern | up-regulated |
| Function Description | LINC00668 is up-regulated in human primary OSCC tissues.We first demonstrated that LINC00668 expression was up-regulated, which was correlated with tumor progression, and miR-297 down-regulated in OSCC tissues and cells. Importantly, LINC00668 expression was negatively correlated with miR-297 expression in OSCC tissues. Loss-of-function of LINC00668 revealed that LINC00668 functioned as a ceRNA for miR-297 to facilitate VEGFA expression, promoting OSCC progression. Finally, we confirmed that LINC00668 promoted OSCC activity through VEGFA signaling.In conclusion, these results suggest that LINC00668 promotes OSCC tumorigenesis via miR-297/VEGFA axis, which may provide a new target for the diagnosis and therapy of OSCC disease. |
| Pubmed ID | 28564590 |
| Year | 2017 |
| Title | Long intergenic non-coding RNA 668 regulates VEGFA signaling through inhibition of miR-297 in oral squamous cell carcinoma. |
| External Links |
| Links for LINC00668 | GenBank HGNC lncrnadb Noncode |
| Links for oral squamous cell carcinoma | Omim Cosmic |
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