Detail
| LncRNA Name | LINC00673 |
| Synonyms | LINC00673, HI-LNC75, HILNC75, LUCAIR1, SLNCR, SLNCR1, ERRLR01 |
| Region | GRCh38_17:72403322-72592804 Sequence |
| Ensembl | NA |
| RefSeq | NR_036488 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 M8170/3 |
| Methods | qPCR, Luciferase reporter assay, Western blot, RNAi |
| Sample | hepatocellular carcinoma tissues, cell lines (HCCLM3, MHCC97L,HepG2, Hep3B and Huh7,THLE-3, L-02) |
| Expression Pattern | up-regulated |
| Function Description | LINC00673 was upregulated in HCC cancerous tissue. LINC00673 overexpression is associated with poor prognosis and low survival rate. LINC00673 silencing inhibited the proliferation,invasion and epithelial-mesenchymal transition (EMT) of HCC cells in vitro. miR-205 targeted 3'-UTR of LINC00673.miR-205 could reverse the effect of LINC00673 on HCC cells.LINC00673 silencing reduced the tumor volume and weight. |
| Pubmed ID | 29312806 |
| Year | 2017 |
| Title | Long non-coding RNA LINC00673 promotes hepatocellular carcinoma progression and metastasis through negatively regulating miR-205 |
| External Links |
| Links for LINC00673 | GenBank HGNC lncrnadb Noncode |
| Links for hepatocellular carcinoma | Omim Cosmic |
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