Detail
| LncRNA Name | ANRIL |
| Synonyms | CDKN2B-AS1, ANRIL, CDKN2B-AS, CDKN2BAS, NCRNA00089, PCAT12, p15AS |
| Region | GRCh38_9:21994778-22121097 Sequence |
| Ensembl | ENSG00000240498 |
| RefSeq | NR_003529 |
| Circulating | ✔ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | oral cancer |
| ICD-0-3 | C06.9 |
| Methods | qPCR,Luciferase reporter assay, in vitro knockdown etc. |
| Sample | cell lines (HB56, HB96, TSCC, Tca8113, SCC-9 and CAL27,HIOECï¼?HEK-293T),oral cancer tissues |
| Expression Pattern | up-regulated |
| Function Description | ANRIL showed significantly higher, while miR-125a showed lower, expression in OC tissues and sera than in normal controls. MTT, colony formation, flow cytometry analysis, wound-healing, transwell and mice xenograft model assays were used to detect the proliferation, migration, and invasion of ARNIL-overexpressing HB56 cells and ARNIL-knockdown CAL27 cells. The results showed that cell proliferation, migration, and invasion were significantly increased by ARNIL overexpression and decreased by ARNIL silencing in oral cancer cells. Furthermore, we found a negative correlation between ARNIL and miR-125a, and ARNIL acts as a miRNA-sponge by directly interacting with miR-125a. |
| Pubmed ID | 29635126 |
| Year | 2018 |
| Title | The role of long non-coding RNA ANRIL in the carcinogenesis of oral cancer by targeting miR-125a. |
| External Links |
| Links for ANRIL | GenBank HGNC lncrnadb Noncode |
| Links for oral cancer | Omim Cosmic |
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