Detail
| LncRNA Name | LINC00894-002 |
| Synonyms | NA |
| Region | NA Sequence |
| Ensembl | NA |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot etc. |
| Sample | cell lines (MCF-7/WT and MCF-7/TamR) |
| Expression Pattern | down-regulated |
| Function Description | LINC00894-002 exhibits the most sophisticated network pattern and is the most downregulated lncRNA in MCF-7/TamR cells. Moreover,LINC00894-002 is directly upregulated by ERa.Knocking down LINC00894-002 downregulates expression of miR-200a-3p and miR-200b-3p, upregulates the expression of TGF-B2 and ZEB1,and finally contributes to TamR.Herein, we report the first case of an inhibitory lncRNA against TamR through the miR-200-TGF-B2-ZEB1 signaling pathway. |
| Pubmed ID | 29738694 |
| Year | 2018 |
| Title | Downregulation of LINC00894-002 Contributes to Tamoxifen Resistance by Enhancing the TGF-B Signaling Pathway. |
| External Links |
| Links for LINC00894-002 | GenBank HGNC lncrnadb Noncode |
| Links for breast cancer | Omim Cosmic |
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