Detail
| LncRNA Name | LINC00958 |
| Synonyms | NA |
| Region | GRCh38_11:12961842-12989548 Sequence |
| Ensembl | ENSG00000251381 |
| RefSeq | NR_038904 |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | microarray, qPCR, Northern blot, RNA pull-down assay etc. |
| Sample | bladder cancer tissues, cell lines (RT4, HT1376, HT1197, T24, J82, UMUC3 etc.) |
| Expression Pattern | differential expression |
| Function Description | Silencing of LINC00958 or LINC01296 in vitro reduced both cell viability and migration. Knock-down of LINC00958 also affected invasion and resistance to anoikis. These cellular effects could be linked to direct/indirect regulation of protein coding mRNAs involved in cell death/survival, proliferation and cellular movement. Finally, we showed that LINC00958 binds proteins involved in regulation and initiation of translation and in post-transcriptional modification of RNA, including Metadherin, which has previously been associated with BC. |
| Pubmed ID | 28341852 |
| Year | 2017 |
| Title | Profiling of long non-coding RNAs identifies LINC00958 and LINC01296 as candidate oncogenes in bladder cancer. |
| External Links |
| Links for LINC00958 | GenBank HGNC lncrnadb Noncode |
| Links for bladder cancer | Omim Cosmic |
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