Detail
| LncRNA Name | LINC00959 |
| Synonyms | NA |
| Region | GRCh38_10:130063896-130110817 Sequence |
| Ensembl | NA |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, RNAi etc. |
| Sample | human colon cancer cell lines (HCT116, SW480) |
| Expression Pattern | down-regulated |
| Function Description | In vitro, LINC00959 knockdown enhanced colon cancer cell proliferation, invasion, and migration; upregulated N-cadherin and vimentin; and downregulated E-cadherin and Caspase-3. LINC00959 overexpression produced the opposite effects. These data suggest that LINC00959 inhibits tumor cell invasion and migration by suppressing epithelial-mesenchymal transition and promotes apoptosis through Caspase-3. LINC00959 may be a tumor suppressor and useful prognostic biomarker in CRC.Survival analysis for LINC00959 expression in 116 CRC patients from the OncoLnc database. (P=0.0218) |
| Pubmed ID | 29228592 |
| Year | 2017 |
| Title | Long non-coding RNA LINC00959 predicts colorectal cancer patient prognosis and inhibits tumor progression. |
| External Links |
| Links for LINC00959 | GenBank HGNC lncrnadb Noncode |
| Links for colorectal cancer | Omim Cosmic |
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