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   LncRNA Name LINC01088
   Synonyms NA
   Region GRCh38_4:78971748-79308798    Sequence
   Ensembl ENSG00000249307
   RefSeq NR_038342
   Circulating
   Drug-resisitant
   Prognostic
   MiRNA
   Variant
   TF
   Methylation
   Cancer Name ovarian cancer
   ICD-0-3 C56.9  
   Methods Microarray, RT-qPCR, Western blot, Luciferase reporter assay
   Sample malignant epithelial ovarian tumor tissue, human ovarian cancer cell line A2780
   Expression Pattern down-regulated
   Function Description

the expression of long intergenic non-coding RNA 1088 (LINC01088) was clearly reduced in benign epithelial ovarian tumor tissues compared to matched normal ovarian tissues. This was shown by global cDNA gene chip scanning and real-time qPCR, and validated in 42 clinical specimens.Furthermore, we found that LINC01088 inhibited the growth of ovarian cancer xenografts in nude mice.Correlation analysis between LINC01088 and mircoRNAs (miRNAs) conducted using primary clinical samples and RNA co-precipitation experiments revealed that miR-24-1-5p was one of the targets of LINC01088. Overexpression of miR-24-1-5p facilitated cell proliferation both in vitro and in vivo, however, LINC01088 could partially reverse the cell proliferation induced by miR-24-1-5p.

   Pubmed ID 29440672
   Year 2018
   Title LINC01088 inhibits tumorigenesis of ovarian epithelial cells by targeting miR-24-1-5p.
   External Links
   Links for  LINC01088 GenBank       HGNC       lncrnadb       Noncode
   Links for  ovarian cancer Omim       Cosmic

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