Lnc2Cancer

Experimentally Supported Human LncRNA and Cancer Associations Database

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   LncRNA Name LINC01133
   Synonyms lncRNA-PAGBC
   Region GRCh38_1:159961218-159984750    Sequence
   Ensembl ENSG00000224259
   RefSeq NR_038849
   Circulating
   Drug-resisitant
   Prognostic
   MiRNA
   Variant
   TF
   Methylation
   Cancer Name colorectal cancer
   ICD-0-3 C19.9  
   Methods qPCR, Western blot, RIP etc.
   Sample cell lines (HT29, HCT8, LS513, SW620, and HCT116)
   Expression Pattern down-regulated
   Function Description

Here we reported a novel lncRNA, LINC01133 that was downregulated by TGF-B, which could inhibit epithelial-mesenchymal transition (EMT) and metastasis in colorectal cancer (CRC) cells. An alternative splicing factor SRSF6 was identified to directly interact with LINC01133, and SRSF6 promoted EMT and metastasis in CRC cells independent of LINC01133 And we confirmed that the EMT process was regulated by LINC01133 in CRC cells dependent on the presence of SRSF6.

   Pubmed ID 27443606
   Year 2016
   Title Long non-coding RNA LINC01133 inhibits epithelial-mesenchymal transition and metastasis in colorectal cancer by interacting with SRSF6.
   External Links
   Links for  LINC01133 GenBank       HGNC       lncrnadb       Noncode
   Links for  colorectal cancer Omim       Cosmic

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