Detail
| LncRNA Name | LINC01133 |
| Synonyms | lncRNA-PAGBC |
| Region | GRCh38_1:159961218-159984750 Sequence |
| Ensembl | ENSG00000224259 |
| RefSeq | NR_038849 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 M8046/3 |
| Methods | qPCR, RNAi, Western blot, RIP, Flow cytometry assay, Cell proliferation assay etc. |
| Sample | NSCLC tissues, cell lines (PC9, SPC-A1, NCI-H1975, H1299, and A549) |
| Expression Pattern | up-regulated |
| Function Description | Here, we found that LINC01133 expression is up-regulated in NSCLC tissues, and its' over-expression is associated with patients poor prognosis and short survival time. LINC01133 knockdown decreased NSCLC cells proliferation, migration, invasion and induced cell cycle G1/S phase arrest and cell apoptosis. Mechanistic investigations showed that LINC01133 could interact with EZH2, LSD1 and recruit them to KLF2, P21 or E-cadherin promoter regions to repress their transcription. Furthermore, rescue experiments demonstrated that LINC01133 oncogenic function is partly through regulating KLF2. |
| Pubmed ID | 26840083 |
| Year | 2016 |
| Title | Long non-coding RNA LINC01133 represses KLF2, P21 and E-cadherin transcription through binding with EZH2, LSD1 in non small cell lung cancer. |
| External Links |
| Links for LINC01133 | GenBank HGNC lncrnadb Noncode |
| Links for non small cell lung cancer | Omim Cosmic |
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