Detail
| LncRNA Name | LINC01296 |
| Synonyms | DUXAP9, LINC01296, FLJ39632, lncRNA-CTD903 |
| Region | GRCh38_14:19062316-19131167 Sequence |
| Ensembl | ENSG00000225210 |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot |
| Sample | gastric cancer tissues, cell lines (SGC-7901, BGC-823, MGC-803, and MKN-45,GES-1) |
| Expression Pattern | up-regulated |
| Function Description | LINC01296 was up-regulated in GC tissue and correlated with poor prognosis.LINC01296 knockdown significantly inhibited GC tumor growth. LINC01296 sponged miR-122,LINC01296 was positively correlated with MMP-9 expression, while miR-122 was negatively correlated to it. Overall,results indicate that LINC01296 acts as oncogenic lncRNA in GC carcinogenesis, suggesting the LINC01296/miR-122/MMP-9 regulatory pathway in GC tumorigenesis.GC patients with high LINC01296 levels had poor overall survivals than that with low LINC01296 level. |
| Pubmed ID | 29091895 |
| Year | 2017 |
| Title | Long intergenic noncoding RNA 01296 aggravates gastric cancer cells progress through miR-122/MMP-9. |
| External Links |
| Links for LINC01296 | GenBank HGNC lncrnadb Noncode |
| Links for gastric cancer | Omim Cosmic |
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