Detail
| LncRNA Name | LINC01296 |
| Synonyms | DUXAP9, LINC01296, FLJ39632, lncRNA-CTD903 |
| Region | GRCh38_14:19062316-19131167 Sequence |
| Ensembl | ENSG00000225210 |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | qPCR, RIP etc. |
| Sample | colon carcinoma tissues, cell lines(CCD841a, SW480, DLD-1, HCT116, SW620, Caco-2 and HT29) |
| Expression Pattern | up-regulated |
| Function Description | LINC01296 was upregulated in CC cancerous tissues and cell lines compared to adjacent normal tissue and normal liver cell lines. Besides, LINC01296 overexpression was associated with poor prognostic and lower survival rate.Moreover, LINC01296 silencing inhibited the proliferation, invasion of CC cells in vitro detected by epithelialmesenchymal transition (EMT). Bioinformatics analysis revealed that miR-21a targeted 3'-UTR of LINC01296. Rescue experiments confirmed that miR-21a could reverse the function of LINC01296 on CC cells.The expression of LINC01296 and mir-21a is negatively correlated in CC. |
| Pubmed ID | 29673421 |
| Year | 2018 |
| Title | Long noncoding RNA LINC01296 harbors miR-21a to regulate colon carcinoma proliferation and invasion. |
| External Links |
| Links for LINC01296 | GenBank HGNC lncrnadb Noncode |
| Links for colon cancer | Omim Cosmic |
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