Detail
| LncRNA Name | linc-ITGB1 |
| Synonyms | ITGB1, CD29, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB |
| Region | GRCh38_10:32900319-33005792 Sequence |
| Ensembl | ENSG00000150093 |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, RNAi, Western blot, Flow cytometry assay etc. |
| Sample | breast cancer tissues, cell lines (MDA-MB-231, MCF-7, T47D, ZR-75-30, 1590 etc.) |
| Expression Pattern | up-regulated |
| Function Description | The expression of linc-ITGB1 was significantly upregulated in both clinical breast cancer tissues and cultured breast cancer cell lines. Linc-ITGB1 depletion caused cell accumulation in the G0/G1 phase. Furthermore, the linc-ITGB1 knockdown decreased the expression of mesenchymal markers N-cadherin and vimentin while increasing the expression of the epithelial marker E-cadherin. Key cell cycle regulators Cdc25C and Cyclin B1 were also decreased by the linc-ITGB1 knockdown. These data suggest that linc-ITGB1 promotes breast cancer progression by inducing cell-cycle arrest and interrupting the epithelial-to-mesenchymal transition (EMT) process. |
| Pubmed ID | 26601916 |
| Year | 2015 |
| Title | Long non-coding RNA linc-ITGB1 promotes cell migration and invasion in human breast cancer. |
| External Links |
| Links for linc-ITGB1 | GenBank HGNC lncrnadb Noncode |
| Links for breast cancer | Omim Cosmic |
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