Detail
| LncRNA Name | LINC-PINT |
| Synonyms | LINC-PINT, LincRNA-Pint, MKLN1-AS1, PINT, FLJ43663 |
| Region | GRCh38_7:130938963-131110176 Sequence |
| Ensembl | ENSG00000231721 |
| RefSeq | NR_015431 |
| Circulating | ✔ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✔ |
| Methylation | ✘ |
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 M8140/3 |
| Methods | qPCR, microarry, RIP etc. |
| Sample | cell lines (HCT116, A549) |
| Expression Pattern | down-regulated |
| Function Description | Here we characterize the function of the p53-regulated human lncRNA LINC-PINT in cancer. We find that LINC-PINT is downregulated in multiple types of cancer and acts as a tumor suppressor lncRNA by reducing the invasive phenotype of cancer cells. A cross-species analysis identifies a highly conserved sequence element in LINCPINT that is essential for its function. This sequence mediates a specific interaction with PRC2, necessary for the LINC-PINT-dependent repression of a pro-invasion signature of genes regulated by the transcription factor EGR1. |
| Pubmed ID | 29078818 |
| Year | 2017 |
| Title | The human lncRNA LINC-PINT inhibits tumor cell invasion through a highly conserved sequence element |
| External Links |
| Links for LINC-PINT | GenBank HGNC lncrnadb Noncode |
| Links for lung adenocarcinoma | Omim Cosmic |
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