Detail
| LncRNA Name | LINC-PINT |
| Synonyms | LINC-PINT, LincRNA-Pint, MKLN1-AS1, PINT, FLJ43663 |
| Region | GRCh38_7:130938963-131110176 Sequence |
| Ensembl | ENSG00000231721 |
| RefSeq | NR_015431 |
| Circulating | ✔ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | acute lymphoblastic leukemia |
| ICD-0-3 | M9835/3 |
| Methods | Microarray, qPCR |
| Sample | B-ALL cell lines (TOM-1, 697, MY, NALM-20, SEM, REH, and TANOUE) and T-ALL cell lines (MOLT-4, HSB2, CEM-CCRF, JURKAT, KE37, HPB-ALL, P12-ICHIKAWA, PEER) |
| Expression Pattern | down-regulated |
| Function Description | linc-PINT showed a significant downregulation in T and B-ALL. Re-expression of linc-PINT in ALL cells induced inhibition of leukemic cell growth that was associated with apoptosis induction and cell cycle arrest in G2/M phase. linc-PINT induced the transcription of HMOX1 which reduced the viability of ALL cells. Intriguingly, we observed that treatment with anti-tumoral epigenetic drugs like LBH-589 (Panobinostat) and Curcumin induced the expression of linc-PINT and HMOX1 in ALL. |
| Pubmed ID | 29560114 |
| Year | 2018 |
| Title | Deregulation of linc-PINT in acute lymphoblastic leukemia is implicated in abnormal proliferation of leukemic cells. |
| External Links |
| Links for LINC-PINT | GenBank HGNC lncrnadb Noncode |
| Links for acute lymphoblastic leukemia | Omim Cosmic |
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