Detail
| LncRNA Name | linc-POU3F3 |
| Synonyms | POU3F3, BRN1, OTF8, brain-1 |
| Region | GRCh38_2:104855511-104858574 Sequence |
| Ensembl | ENSG00000198914 |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✔ |
| Cancer Name | esophageal squamous cell cancer |
| ICD-0-3 | |
| Methods | qPCR, Western blot, RIP, Luciferase reporter assay etc. |
| Sample | ESCC tissues |
| Expression Pattern | up-regulated |
| Function Description | Levels of a lincRNA encoded by a gene located next to POU3F3 (linc-POU3F3) were significantly higher in ESCC than neighboring nontumor tissues. In RNA immunoprecipitation assays, linc-POU3F3 was associated with the EZH2 messenger RNA (mRNA). Overexpression of linc-POU3F3 in cell lines increased their proliferation and ability to form colonies, and reduced the expression of POU3F3 mRNA, whereas knockdown of linc-POU3F3 increased the levels of POU3F3 mRNA. |
| Pubmed ID | 24631494 |
| Year | 2014 |
| Title | Increased levels of the long intergenic non-protein coding RNA POU3F3 promote DNA methylation in esophageal squamous cell carcinoma cells. |
| External Links |
| Links for linc-POU3F3 | GenBank HGNC lncrnadb Noncode |
| Links for esophageal squamous cell cancer | Omim Cosmic |
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