Detail
| LncRNA Name | lincRNA-p21 |
| Synonyms | TP53COR1, linc-p21, lincRNA-p21 |
| Region | NA Sequence |
| Ensembl | NA |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✔ |
| TF | ✔ |
| Methylation | ✘ |
| Cancer Name | glioma |
| ICD-0-3 | M9380/3 |
| Methods | qPCR, Western blot etc. |
| Sample | cell lines (SMMC7721, U251MG) |
| Expression Pattern | down-regulated |
| Function Description | In this work, we found that X-ray irradiation or hypoxia treatment elevated lincRNA-p21 expression in SMMC7721 hepatoma and U251MG glioma cells.High lincRNA-p21 levels were associated with poor cancer-specific survival in patients. F.. However, tumor cells can express a wide range of transcription factors, such as hypoxia-inducible factor-1a (HIF-1a).found that LincRNA-p21 was downregulated in non-small-cell lung cancer tissue, but no association was observed with TP53 mutational status. |
| Pubmed ID | 28689810 |
| Year | 2017 |
| Title | LincRNA-p21 knockdown enhances radiosensitivity of hypoxic tumor cells by reducing autophagy through HIF-1/Akt/mTOR/P70S6K pathway. |
| External Links |
| Links for lincRNA-p21 | GenBank HGNC lncrnadb Noncode |
| Links for glioma | Omim Cosmic |
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